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October 2018: AI based personalized prognostic models in cancer

Featuring Aziz Nazha MD

01 October, 2018


Dr. Aziz Nazha, Assistant Professor, Taussig Cancer Center, Cleveland Clinic started the October, BrainX Community live event by making a case for artificial intelligence applications  in medicine.He then went on to showcase some of the prognostic models in cancer that have been developed by his team and applications there of in personalized medicine.Newer models  using traditional recommender systems can be developed which use genomic biomarkers to predict response to therapy in a much more accurate manner than traditional methods.He also showed how neural networks can help in drug development and to target therapies.Integrating the work of pathomics and radiomics into cancer management along with electronic medical records data will hopefully build better treatment care paths in the future for more effective personalized care.

The Complexity of Interpreting Genomic Data in Patients with Primary and Secondary Acute Myeloid Leukemia (AML)
Aziz NazhaAhmad ZarzourTomas RadivoyevitchHetty E. CarrawayJennifer S. CarewCassandra M HirschKassy E KneenBartlomiej PrzychodzenBhumika J. PatelMichael ClementeSrinivasa R. SanikommuMatt KalaycioJaroslaw P. Maciejewski and Mikkael A. Sekeres
The Revised International Prognostic Scoring System “Molecular” (IPSS-Rm), a Validated and Dynamic Model in Treated Patients with Myelodysplastic Syndromes (MDS)
Aziz NazhaMayur Subhash NarkhedeTomas RadivoyevitchMatt KalaycioBhumika J. PatelAaron T. GerdsSudipto MukherjeeMichael ClementeCassandra M HirschAnjali S. AdvaniBartlomiej PrzychodzenHetty E. CarrawayJaroslaw P. Maciejewski and Mikkael A. Sekeres
The efficacy of current prognostic models in predicting outcome of patients with myelodysplastic syndromes at the time of hypomethylating agent failure
Aziz Nazha, Rami S. Komrokji, Guillermo Garcia-Manero, John Barnard, Gail J. Roboz,David P. Steensma, Amy E. DeZern, Katrina Zell,Cassie Zimmerman, Najla Al Ali, Elias Jabbour,Molly D. Greenberg, Hagop M. Kantarjian, Jaroslaw P. Maciejewski, Alan F. List, and Mikkael A. Sekeres, On behalf of the MDS Clinical Research Consortium
Haematologica. 2016 Jun; 101(6): e224–e227.